Case: Similarity Metrics

A 55-year-old male patient with a history of glioblastoma multiforme is undergoing routine follow-up MRI scans to monitor tumor progression. The radiology department has acquired two MRI scans taken three months apart. The radiologist must use similarity metrics to assess any changes in the tumor size and characteristics to determine the effectiveness of the ongoing treatment.

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The first MRI scan shows a hyperintense lesion in the right frontal lobe with surrounding edema. The follow-up MRI scan, taken three months later, needs to be compared to the initial scan to evaluate changes in the lesion's size and intensity.

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Which similarity metric would be most appropriate to use for comparing these MRI scans?